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Friday, 1 November 2013

Non-Small Cell Lung Cancer Study Information from ASCO 2013

Posted on 03:00 by Unknown
Christine Wilson, cancer survivor, shares her experiences from the The American Society of Clinical Oncologists (ASCO) national conference in 2013. Every year, over 30,000 cancer specialists and researchers from around the world gather to present their latest findings on the prevention, diagnosis and treatment of science. At a recent continuing medical education meeting, experts from the Abramson Cancer Center summarized some of the most important research from ASCO 2013 for a packed room of over 300 local oncologists. 

In this article, Chris discusses a presentation about studies for non-small cell lung cancer from Penn Medicine's Director of Thoracic Oncology, Corey Langer, MD.

Locally Advanced Disease

  • START Trial: MUC1 is often over expressed in lung cancer. In preclinical studies, a vaccine produced an increase in T-cells or an immunotherapy response. The START trial is a large phase III study for patients with stage III lung cancer with either stable disease or an objective response to chemo and radiation therapy. These patients received the MUC 1 vaccine for eight weeks. Although, overall, the trial did not extend overall survival, the group of patients who received their chemo and radiation at the same time did have a 10 month advantage in overall survival. The reasons for this are not entirely clear, but may result from a combination of factors.

Advanced Disease

  • PROSE Trial: VeriStrat testing is a new way of profiling lung cancers based on a number of prognostic factors. The PROSE trial studied whether VeriStrat has any predictive value in determining the success of chemotherapy and targeted therapy. The results did not show any difference between the two arms for the VeriStrat Good patients, but the VeriStrat Poor patients receiving chemotherapy did better than those receiving the targeted therapy.
  • Ganestespib is a novel agent that inhibits the Hsp-90 pathway which is over expressed in cancer cells. The GALAXY trial compared ganestespib alone with ganestespib and daclataxel. In patients with advanced lung cancer, earlier trials have shown that patients who did well on previous therapies are more likely to do better with this agent.
  • Anti-PD-1. This trial uses nivolumab with advanced lung cancer patients who have been heavily pretreated. Response rates for both squamous and non-squamous cell patients have been in the 20 to 25% range. This is promising, and can be easily administered in an outpatient setting.


Penn Medicine's Abramson Cancer Center is leading the way in breakthrough cancer treatment. If you or someone you know has been touched by cancer, the power to find the Cure is Within.


Hear our stories and find out more today.

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